Particle Concentration Measurement
Particle Concentration is a critical parameter for understanding the number of particles within a specific volume of a sample. With Particle Metrix’s ZetaView® systems, you can achieve precise and reliable particle concentration measurements while simultaneously analyzing additional parameters such as particle size. This integrated approach provides comprehensive insights for a variety of applications across industries.
What is Particle Concentration?
Particle Concentration refers to the quantification of particles in a given volume of a liquid suspension, typically expressed as particles per milliliter (particles/ml). This measurement provides essential data for evaluating particle behavior, ensuring sample consistency, and optimizing processes in research and industrial applications.
Knowing particle concentration is crucial for ensuring reproducibility in experiments, maintaining product quality, and predicting the performance of materials under different conditions. High-precision particle concentration analysis enables researchers to, fine-tune isolation procedures, optimize formulations and ensure accurate dosing in fields such as pharmaceuticals, environmental science, and materials research. Key Attributes of Particle Concentration Analysis:
Quantitative Data: Provides exact counts of particles within a defined volume, offering insights into sample composition and uniformity.
Applicability Across Materials: Suitable for a wide range of sample types, including nanoparticles and complex biological materials.
Why is Particle Concentration important?
Particle concentration plays a vital role in numerous scientific and industrial processes, directly impacting product quality, stability, and functionality. For example:
In pharmaceuticals, precise particle counts are necessary to ensure accurate drug dosing and uniform delivery.
In biotechnology, knowing particle concentration helps in the study of biologically relevant particles such as Extracellular Vesicles (EVs) and liposomes.
In environmental science, particle concentration measurements help assess pollution levels, sedimentation, and nanoparticle behavior in ecosystems.
Accurate particle concentration analysis supports reproducible research and reliable product performance across applications.
How is particle concentration measured?
Particle concentration is measured using advanced systems like the ZetaView® analyzer, which uses Nanoparticle Tracking Analysis (NTA) with high-sensitivity imaging to detect even very small particles. During the measurement process:
- A sample is illuminated with a laser, and individual particles are detected using a high-resolution CMOS camera.
- The system identifies and counts the particles within the field of view.
- By knowing the sample volume analyzed, the ZetaView® system calculates the particle concentration in the sample.
This method ensures high accuracy, reproducibility, and the ability to detect even low concentrations and very small particles.
Advanced Particle Concentration Measurement with ZetaView®
Advanced Particle Concentration Measurement with ZetaView®
The ZetaView® system from Particle Metrix offers precise, automated particle concentration measurements, enabling researchers to obtain detailed and reliable data. By integrating additional analysis capabilities, ZetaView® delivers a comprehensive understanding of your samples. Key advantages of ZetaView® for particle concentration analysis include:
Multi-Parameter Measurements
Measure particle concentration alongside size, fluorescence, and zeta potential for a complete profile.
High Sensitivity and Accuracy
Achieve consistent results, even with low concentrations or challenging samples.
Advanced Fluorescence Capabilities Detect and quantify fluorescently labeled subpopulations within complex mixtures.
Automated Sample Handling
Streamlined workflows with minimal operator intervention ensure efficiency.
Tailored Solutions
Analyze a wide range of sample types, including nanoparticles and biological materials.
Applications of Particle Concentration Analysis
Particle Concentration analysis is essential for research, quality control, and development across a variety of disciplines:
Pharmaceuticals: Ensures consistent dosing and uniformity in drug delivery systems, improving therapeutic outcomes.
Biotechnology and Life Sciences: Analyzes concentration of EVs and other biologically relevant particles for diagnostic and therapeutic purposes.
Environmental Science: Evaluates the concentration of nanoparticles in water to monitor pollution and its impact on ecosystems.
Materials Science: Supports the production and performance of advanced materials, such as nanocomposites and catalysts, by ensuring consistent particle counts.
Cosmetics: Monitors particle concentration in emulsions, lotions, and other formulations to guarantee stability and efficacy.
Let’s talk about your Particle Concentration Analysis needs
If you’re interested in learning more about how particle concentration analysis can benefit your research or product development, reach out to our team of experts. We offer personalized consultations, system demonstrations, and technical support to help you achieve your goals.
Frequently asked questions about Particle Concentration
What types of samples can be analyzed for particle concentration?
Size distribution can be measured for all nanoparticles (e.g. extracellular vesicles, nano bubbles, nano metals) within a size range of 10* – 1000nm and a concentration range of 105 – 109 particles/ml.
(*sample and laser dependent)
What are the advantages of using Particle Metrix’s technology for Particle Concentration analysis?
Our patented scanning technology allows the detection of a large sample volume in less than one minute, analyzing thousands of particles in one run. Therefore, our ZetaView delivers statistically highly relevant data.
How do I ensure consistent and accurate Particle Concentration measurements?
The keys to ensuring reliable particle size measurements is a consistent sample preparation as well as the use of a suitable operation protocol as delivered during the instrument training. Additionally, integrated algorithms control consistent measurement conditions through the whole sample volume and indicate outliers.
Can the ZetaView® system measure fluorescently labeled particles?
Yes, the system supports fluorescence measurements, allowing detailed analysis of labeled subpopulations within your sample. Depending on the chosen model (MONO, TWIN, QUATT) and the number of implemented fluorescent filters, the ZetaView features the analysis of up to 10 different fluorescent channels.
